Silver Inlaid with Gold Nanoparticles: Enhanced Antibacterial Ability Coupled with the Ability to Visualize Antibacterial Efficacy,ACS Sustainable Chemistry & Engineering

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Silver Inlaid with Gold Nanoparticles: Enhanced Antibacterial Ability Coupled with the Ability to Visualize Antibacterial Efficacy
ACS Sustainable Chemistry & Engineering ( IF 7.1 ) Pub Date : 2018-07-05 00:00:00 , DOI: 10.1021/acssuschemeng.8b00931
Qing Li ₁ , Fei Lu _{1,

2} , Hongli Ye ₁ , Kun Yu ₁ , Bitao Lu ₁ , Rong Bao ₃ , Yang Xiao ₄ , Fangyin Dai _{1,

2} , Guangqian Lan _{1,

2}

Affiliation

Silver nanoparticles (Ag NPs) are widely used against bacteria, but further applications are restricted by their cytotoxicity. Their antibacterial efficiency cannot be measured because of the risk of development of multidrug resistance (MDR) with use of antibiotics. An alloy nanostructure of gold nanoparticles (Au NPs) inlaid on Ag NPs was synthesized using egg white protein (denoted here as Au–Ag NPs), exhibiting an enhanced antibacterial effect and can visually indicate the antibacterial efficacy by fluorescence. Interestingly, the fluorescence recovered after antibacterial action. Au–Ag NPs showed enhanced antibacterial effect, due to higher reactive oxygen species (ROS) generation than Ag NPs, after adhering to the surface of bacteria, suggesting that the silver content in Au–Ag NPs can be tuned to reach high antibacterial activity with low cytotoxicity. Au–Ag NPs visualized bacteria by fluorescence changes, which makes the antibacterial process clear and allows the dosage of antibacterial agents to be controlled accurately, which can prevent MDR. Efficient antibacterial activity coupled with the ability to visualize bacterial processes allow Au–Ag NPs to be a potential solution in medicine and biosensing.

中文翻译：

银镶嵌金纳米颗粒：增强的抗菌能力，加上可视化抗菌功效的能力

银纳米颗粒（Ag NPs）被广泛用于抵抗细菌，但进一步的应用受到其细胞毒性的限制。由于使用抗生素可能会产生多药耐药性（MDR），因此无法测量其抗菌效率。使用蛋清蛋白（此处表示为Au–Ag NPs）合成了镶嵌在Ag NPs上的金纳米颗粒（Au NPs）的合金纳米结构，显示出增强的抗菌效果，并可以通过荧光直观地表明抗菌效果。有趣的是，荧光在抗菌作用后恢复了。附着在细菌表面后，由于比Ag NPs产生更高的活性氧（ROS），Au-Ag NPs表现出增强的抗菌作用，提示可以调节Au-Ag NP中的银含量，以达到高抗菌活性和低细胞毒性。Au-Ag NPs通过荧光变化使细菌可视化，这使抗菌过程更加清晰，并且可以精确控制抗菌剂的剂量，从而可以预防MDR。高效的抗菌活性以及可视化细菌过程的能力使Au-Ag NP成为医学和生物传感领域的潜在解决方案。

更新日期：2018-07-05

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