Sour cherry extract inhibits human salivary α-amylase and growth of Streptococcus mutans (a pilot clinical study)†,Food & Function

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Sour cherry extract inhibits human salivary α-amylase and growth of Streptococcus mutans (a pilot clinical study)†
Food & Function ( IF 5.1 ) Pub Date : 2018-07-06 00:00:00 , DOI: 10.1039/c8fo00064f
Judit Homoki _{1,

2,

3,

4,

5} , Gyöngyi Gyémánt _{3,

4,

5,

6,

7} , Péter Balogh _{3,

4,

5,

8,

9} , László Stündl _{1,

2,

3,

4,

5} , Piroska Bíró-Molnár _{1,

2,

3,

4,

5} , Melinda Paholcsek _{3,

4,

5,

10,

11} , Judit Váradi _{3,

4,

5,

12,

13} , Fenyvesi Ferenc _{3,

4,

5,

12,

13} , Barna Kelentey _{3,

4,

5,

14,

15} , Judit Nemes _{3,

4,

5,

15,

16} , Judit Remenyik _{1,

2,

3,

4,

5}

Affiliation

Institute of Food Technology
Faculty of Agricultural and Food Sciences and Environmental Management
University of Debrecen
H-4032 Debrecen
Hungary
Department of Inorganic and Analytical Chemistry
Faculty of Sciences and Technology
Institute of Sectoral Economics and Methodology
Faculty of Economics and Business
Department of Human Genetics
Faculty of Medicine
Department of Pharmaceutical Technology
Faculty of Pharmacy
Department of Restorative Dentistry
Faculty of Dentistry
Department of Pediatric Dentistry and Orthodontics

The purpose of this study was to determine whether cherry extract has any effect on salivary α-amylase activity (sAA) or on the level of Streptococcus mutans in human saliva. 70 patients (45 females and 25 males) in three age groups (22 children, 25 young adults, and 23 adults) were examined. All participants completed a questionnaire to obtain information on their oral health behaviour and life style. Clinical examination was performed to record the number of decayed, missing and filled teeth (DMF-T). Saliva samples were collected for the measurement of sAA and the salivary S. mutans level before and after chewing a gum with or without cherry extract. Statistical evaluation of data was performed. S. mutans and the sAA level of unstimulated saliva samples did not depend on either age or gender. The basal sAA value of adult patients was in linear correlation with the dental caries status. Habitual chewing-gum use decreased the resting sAA and the mean of DMF-T. The number of S. mutans cells was significantly lower in the resting saliva of allergic patients. The applied mechanical and gustatory stimuli by chewing gum resulted in higher sAA and S. mutans levels and a slow decrease of values was observed in the control group for the next 30 min. Thereafter, sAA and S. mutans levels decreased earlier in the presence of sour cherry extract than those of control cases. Chewing gum with sour cherry extract may be useful for the prevention of dental caries.

中文翻译：

酸樱桃提取物抑制人唾液α-淀粉酶和变形链球菌的生长（临床试验研究）†

这项研究的目的是确定樱桃提取物是否对唾液中的唾液α-淀粉酶活性（sAA）或变形链球菌水平有任何影响。在三个年龄段（22名儿童，25名年轻成年人和23名成人）中检查了70名患者（45名女性和25名男性）。所有参与者都填写了一份问卷，以获取有关其口腔健康行为和生活方式的信息。进行临床检查以记录蛀牙，缺失和充满牙齿的数量（DMF-T）。在咀嚼带有或不带有樱桃提取物的口香糖之前和之后，收集唾液样品以测量sAA和唾液变形链球菌水平。对数据进行统计评估。变形链球菌未刺激唾液样品的sAA水平与年龄或性别无关。成年患者的基础sAA值与龋齿状态呈线性相关。习惯使用口香糖可降低静息sAA和DMF-T的平均值。在过敏患者的静息唾液中，变形链球菌细胞的数量明显减少。通过口香糖施加的机械和味觉刺激导致较高的sAA和变形链球菌水平，并且在接下来的30分钟内，对照组的值缓慢下降。此后，在存在酸性樱桃提取物的情况下，sAA和变形链球菌的水平较对照组下降得更早。带有酸性樱桃提取物的口香糖可能对预防龋齿有用。

更新日期：2018-07-06

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