Mannan-oligosaccharide modulates the obesity and gut microbiota in high-fat diet-fed mice†,Food & Function

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Mannan-oligosaccharide modulates the obesity and gut microbiota in high-fat diet-fed mice†
Food & Function ( IF 5.1 ) Pub Date : 2018-07-05 00:00:00 , DOI: 10.1039/c8fo00209f
Hongshan Wang _{1,

2,

3,

4} , Xiaojuan Zhang _{2,

3,

4,

5} , Shanshan Wang _{1,

2,

3,

4} , Heng Li _{1,

2,

3,

4} , Zhenming Lu _{2,

3,

4,

5} , Jinsong Shi _{1,

2,

3,

4} , Zhenghong Xu _{2,

3,

4,

5,

6}

Affiliation

The gut microbiota is considered to be associated with high-fat diet (HFD)-induced obesity and metabolic syndrome (MS). Mannan-oligosaccharide (MOS) is widely used as a natural additive, and its effect on promoting fat metabolism has been reported. Here, we performed a 11-week study on C57BL/6J mice fed a high-fat diet (HFD) with/without MOS supplementation, and the results showed that MOS could attenuate high-fat diet induced metabolic syndrome, including slower body weight gain, lowered serum lipids and reduced insulin resistance. Next generation sequencing (NGS) of the gut microbiota indicated that MOS modulated the overall structure of the gut microbiome, which was highly correlated with MS parameters. Specifically, the intake of MOS decreased the Firmicutes/Bacteroidetes ratio and could reverse the changes in the relative abundance of several species caused by HFD, including Akkermansia muciniphila, Bacteroides acidifaciens, Lactobacillus gasseri and Bifidobacterium pseudolongum. Thus, MOS has the potential to be used as a new prebiotic for regulating the gut microbiota and helping in attenuating metabolic disorders.

中文翻译：

甘露寡糖调节高脂饮食喂养小鼠的肥胖和肠道微生物†

肠道菌群被认为与高脂饮食（HFD）引起的肥胖症和代谢综合征（MS）有关。甘露寡糖（MOS）被广泛用作天然添加剂，并且已经报道了其对促进脂肪代谢的作用。在这里，我们对饲喂高脂饮食（HFD）并添加或不添加MOS的C57BL / 6J小鼠进行了为期11周的研究，结果表明MOS可以减轻高脂饮食诱发的代谢综合征，包括减慢体重增加，降低血脂和降低胰岛素抵抗。肠道菌群的下一代测序（NGS）表明，MOS调节了肠道微生物组的整体结构，这与MS参数高度相关。具体来说，Akkermansia muciniphila，Bacteroides acidifaciens，gasseri gasseri和Bifidobacterium pseudolongum。因此，MOS有潜力用作调节肠道菌群并减轻新陈代谢紊乱的新型益生元。

更新日期：2018-07-05

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