Biomimetic membrane technology, based on the use of nano-scale functional additives in the form of channel proteins or artificially made channel structures, represents an attractive way of optimizing membrane separation technology. However, the nano-scale nature of the additives inherently points to the challenge in up-scaling the membranes to square meter areas. Thus, the ability to up-scale the processes involved in manufacturing will be crucial for translating the protein/nano-science into technology. Here we discuss how highly selective aquaporin proteins can be used to enhance the performance of the classical thin film composite membrane, and how this can be used in relevant membrane elements and module form factors. A particular up-scaling challenge lies in securing large scale membrane protein production. We demonstrate our framework for making batch amounts which are compatible with the large scale production of biomimetic membranes for water purification based on the use of the E. coli expression system.

中文翻译：

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从通道蛋白到工业仿生膜技术

仿生膜技术基于使用通道蛋白或人工制造的通道结构形式的纳米级功能性添加剂，是优化膜分离技术的一种有吸引力的方式。然而，添加剂的纳米级性质固有地指出了将膜放大至平方米面积的挑战。因此，扩大生产过程的能力对于将蛋白质/纳米科学转化为技术至关重要。在这里，我们讨论如何将高度选择性的水通道蛋白蛋白质用于增强经典薄膜复合膜的性能，以及如何将其用于相关的膜元件和模块形状因子中。扩大规模的挑战在于确保大规模的膜蛋白生产。大肠杆菌表达系统。