This manuscript describes, for the first time, the multi-residue analysis of 18 chiral pesticides at enantiomeric levels in both environmental liquid (river water, influent and effluent wastewater) and solid matrices (agricultural soil, forestal soil and river sediment) based on magnetic solid-phase extraction (MSPE) and chiral liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS). Magnetic amino modified multiwalled carbon nanotubes (m-MWCNTs-NH₂) were prepared and firstly applied to adsorb pesticides from complex matrices. Response surface methodology (RSM) was applied to assist the multivariable optimization. The simultaneous enantioseparation of the chiral pesticides was performed on a Chiralpak IG column. Under the optimum conditions, the mean recoveries for pesticides enantiomers from the water matrices ranged from 81.1 to 106.3% with intra-day RSD of 2.1–11.9% and inter-day RSD of 2.6–12.7%; the mean recoveries for all enantiomers from the solid matrices ranged from 80.3 to 105.9% with intra-day RSD of 2.3–10.9% and inter-day RSD of 4.0–13.4%. Good linearity was achieved for all enantiomers with determination coefficients (r²) greater than 0.9912. Method quantification limits were below 2.04 ng L⁻¹ in liquid matrices and below 0.50 ng g^-1 in solid matrices. The developed method offered some advantages, such as simple operation, rapidity and high concentration factor. Therefore, it is suitable for monitoring the enantiomeric compositions of chiral pesticides in different environmental matrices.

该手稿首次描述了基于磁性的18种手性农药在环境液体（河流水，进水和出水废水）和固体基质（农业土壤，森林土壤和河流沉积物）中对映体水平的多残留分析固相萃取（MSPE）和手性液相色谱-串联质谱（LC-MS / MS）。磁性氨基修饰的多壁碳纳米管（m-MWCNTs-NH ₂制备），并首先用于吸附复杂基质中的农药。响应面方法（RSM）被应用于协助多变量优化。在Chiralpak IG色谱柱上同时进行手性农药的对映体分离。在最佳条件下，水基质中农药对映体的平均回收率在81.1％至106.3％之间，日内RSD为2.1-11.9％，日间RSD为2.6-12.7％；固体基质中所有对映异构体的平均回收率在80.3％至105.9％之间，日内RSD为2.3-10.9％，日间RSD为4.0-13.4％。所有对映异构体均具有良好的线性，测定系数（r ²）大于0.9912。方法定量限低于2.04 ng L ^-1在液体基质中的含量低于0.50 ng g ^-1在固体基质中。该方法具有操作简单，快速，浓缩系数高等优点。因此，它适用于监测不同环境基质中手性农药的对映体组成。