Contaminants giving rise to emerging concern like pharmaceuticals, personal care products, pesticides and Endocrine Disrupting Chemicals (EDCs) have been detected in wastewaters, as reported in the literature, but little is known about their (eco)toxicological effects and consequent human health impact. The present study aimed at overcoming this lack of information through the use of in silico methods integrated with traditional toxicological risk analysis. This is part of a pilot project involving the management of wastewater treatment plants in the Ledra River basin (Italy). We obtained data to work up a global risk assessment method combining the evaluations of health risks to humans and ecological receptors from chemical contaminants found in this specific area. The (eco)toxicological risk is expressed by a single numerical value, permitting the comparison of different sampling sites and the evaluation of future environmental and technical interventions.

如文献报道，已在废水中检测到引起关注的污染物，如药品，个人护理产品，农药和内分泌干扰化学物质（EDC），但对其（生态）毒理学影响及其对人类健康的影响知之甚少。本研究旨在通过与传统毒理学风险分析相结合的计算机方法克服这种信息的缺乏。这是一项涉及管理项目的试点项目的一部分莱德拉河流域（意大利）的废水处理厂。我们获得了数据，以制定一种全球风险评估方法，该方法结合了在该特定区域发现的化学污染物对人类和生态受体造成的健康风险的评估。（生态）毒理学风险由单个数值表示，可以比较不同的采样地点并评估未来的环境和技术干预措施。