Immunotherapy is a promising strategy to inhibit cancer progression via activation of the immune system. In immunotherapy, adjuvants as immunologic stimulants or delivery systems play a critical role in inducing the antitumor immune response and decreasing the side effects of immune stimulants. Polymer nanoparticles have attracted increasing attention as an indispensable component of immunotherapy, owing to their favorable properties, such as excellent biocompatibility and biodegradability, flexible size, high activity as immune stimulants, large surface area for binding multivalent immune ligands, and high loading capacity for immune-related components. In cancer immunotherapy, polymer nanoparticles can protect cargo from the surrounding milieu, deliver the antigens and immunostimulatory molecules to antigen-presenting cells, or stimulate robust T cell response. This review summarizes the current advancements in polymer nanoparticle adjuvants for cancer immunotherapy and predicts their prospects in fundamental and clinical studies.

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免疫疗法是通过激活免疫系统抑制癌症进展的一种有前途的策略。在免疫疗法中，佐剂作为免疫刺激剂或递送系统在诱导抗肿瘤免疫反应和减少免疫刺激剂的副作用方面起着关键作用。聚合物纳米颗粒具有良好的特性，例如出色的生物相容性和生物降解性，灵活的尺寸，作为免疫刺激剂的高活性，与多价免疫配体结合的大表面积以及对免疫的高负载能力等，已成为越来越多的关注，成为免疫疗法不可或缺的组成部分。相关组件。在癌症免疫疗法中，聚合物纳米颗粒可以保护货物免受周围环境的侵害，将抗原和免疫刺激分子传递至抗原呈递细胞，或刺激强烈的T细胞反应。这篇综述总结了用于癌症免疫治疗的聚合物纳米颗粒佐剂的最新进展，并预测了其在基础和临床研究中的前景。

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