4D Biofabrication: Materials, Methods, and Applications,Advanced Healthcare Materials

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4D Biofabrication: Materials, Methods, and Applications
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-07-05 , DOI: 10.1002/adhm.201800412
Leonid Ionov ₁

Affiliation

The mission of regenerative medicine is the development of methods to regrow, repair, or replace damaged or diseased cells, organs, or tissues. 3D bioprinting techniques are one of the most promising approaches for engineering the design of artificial tissues. Current 3D bioprinting technologies possess, however, several intrinsic limitations. 4D biofabrication, a recently developed technology with the embedded ability of shape transformation upon response to intrinsic and/or external stimuli, may solve challenges of 3D bioprinting as well as more accurately mimic the dynamics of the native tissues. This article covers recent advances in 4D biofabrication. It gives a detailed picture of used materials and technologies, provides critical comparisons of methods, discusses possibilities and limitations of different 4D biofabrication technologies, and gives examples of applications.

中文翻译：

4D生物制造：材料，方法和应用

再生医学的任务是开发再生，修复或替换受损或患病的细胞，器官或组织的方法。3D生物打印技术是对人造组织进行工程设计的最有前途的方法之一。但是，当前的3D生物打印技术具有一些固有的局限性。4D生物制造是一种最新开发的技术，具有对内在和/或外部刺激做出响应时具有嵌入形状转换的能力，可以解决3D生物打印的挑战，并更准确地模拟天然组织的动力学。本文介绍了4D生物加工的最新进展。它详细介绍了使用过的材料和技术，提供了方法的重要比较，讨论了不同4D生物制造技术的可能性和局限性，

更新日期：2018-07-05

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