The study was carried out to evaluate the in vitro antioxidant, α-glucosidase inhibitory potential and the protective effect of Asparagus stipularis Forssk aqueous extract against high-fructose diet (HFD; 10% fructose solution for 5 months) induced metabolic syndrome in rats. An A. stipularis shoots decoction (ASD) was administered orally (100 and 300 mg/kg body weight), daily for 4 weeks. Controls were performed using metformin (150 mg/kg) as a standard drug. HPLC-MS analysis showed hydroxycinnamoyl derivatives and flavonoid glycosides as the major constituents of ASD. Fructose fed rats showed hyperglycemia, dyslipidemia, impaired glucose tolerance and an increase of inflammation markers (alkaline phosphatase, aspartate transaminase and alanine transaminase) together with higher values of lipid peroxidation and lowered activities of antioxidants enzymes in liver. Hepatic histopathological examinations were performed. Variable sized fat vacuoles and diffuse lymphocytic infiltration were observed. ASD treatment prevented these abnormalities, demonstrating its protective effect against HFD-induced metabolic syndrome in rats.

进行了研究以评估体外抗氧化剂，α-葡萄糖苷酶的抑制潜力以及芦笋Forssk水提取物对高果糖饮食（HFD； 10％果糖溶液5个月）诱导的大鼠代谢综合征的保护作用。一个A. stipularis每天口服芽苗汤（ASD）（100和300 mg / kg体重），持续4周。使用二甲双胍（150 mg / kg）作为标准药物进行对照。HPLC-MS分析显示羟基肉桂酰基衍生物和类黄酮糖苷是ASD的主要成分。用果糖喂养的大鼠表现出高血糖，血脂异常，葡萄糖耐量降低和炎症标志物（碱性磷酸酶，天冬氨酸转氨酶和丙氨酸转氨酶）增加，脂质过氧化值升高，肝脏中抗氧化酶活性降低。进行肝组织病理学检查。观察到大小不一的脂肪液泡和弥漫性淋巴细胞浸润。ASD治疗可预防这些异常，显示出其对HFD诱导的大鼠代谢综合征的保护作用。