Solid-state fish oil formulations composed of omega-3 (ω-3)-rich lipid droplets internalised within a nanostructured porous silica matrix have been engineered for the first time to optimise the bioaccessibility of ω-3 fatty acids. Silica-fish oil hybrid (SFOH) particles were fabricated by spray drying a submicron fish oil emulsion stabilised by hydrophilic porous silica particles. The integrity of the bioactive polyunsaturated acyl chain was preserved during synthesis and mid-term storage, highlighting the ability for silica to impart oxidative stability towards PUFA. ¹H NMR analysis elucidated that the nanostructured silica network acted as a substrate-enzyme immobilisation template that facilitated enhanced fish oil hydrolysis kinetics through the interfacial activation of lipolytic enzymes, resulting in a 1.4-fold improvement in bioaccessibility compared to crude fish oil. Subsequently, this novel solid-state fish oil formulation has the potential to overcome stability drawbacks associated with PUFA and optimise the degree of ω-3 absorption into the systematic bloodstream.

由纳米结构多孔二氧化硅基质内部的富含ω-3（ω-3）的脂质滴组成的固态鱼油配方已首次进行工程设计，以优化ω-3脂肪酸的生物利用度。通过喷雾干燥被亲水性多孔二氧化硅颗粒稳定的亚微米鱼油乳液，制备了二氧化硅-鱼油杂化（SFOH）颗粒。生物活性多不饱和酰基链的完整性在合成和中期存储过程中得以保留，突出了二氧化硅赋予PUFA氧化稳定性的能力。^1个1 H NMR分析表明，纳米结构的二氧化硅网络充当底物酶固定模板，通过脂解酶的界面活化促进了鱼油水解动力学的增强，与生鱼油相比，其生物利​​用度提高了1.4倍。随后，这种新颖的固态鱼油配方具有克服与PUFA相关的稳定性缺点的潜力，并可以优化ω-3吸收到系统血流中的程度。