Comprehensive two-dimensional gas chromatography (GC × GC) has impacted the workflow of GC-based methods used in petroleum industry. Application of GC × GC to petroleomic investigations have guided sample preparation to faster, cleaner, and more reliable formats. For instance, solvent consumption has been drastically reduced when using miniaturized devices in routine applications. Furthermore, flow-modulation has enabled cost-effective analysis and powerful separations of gases, fuels, and crude oils. Hyphenation of GC × GC to conventional and high resolution mass spectrometry has enabled the detection and identification of hundreds of compounds in a single analysis. Pixel-based methods enabled efficient handling of big data generated by GC × GC in forensic and geochemical investigations. This review has highlighted an ever-growing demand for modern and powerful analytical methods for oil & gas industry. Here, we described the most recent advances to sample preparation, GC × GC instrumentation, and multivariate data analysis in petroleum industry, including microextractions, high temperature GC × GC, and pixel-based data analysis.

全面的二维气相色谱（GC×GC）影响了石油工业中基于GC的方法的工作流程。GC×GC在石油勘探中的应用已将样品制备指导为更快，更清洁和更可靠的形式。例如，在常规应用中使用小型化设备时，溶剂消耗已大大减少。此外，流量调节技术能够进行具有成本效益的分析，并对气体，燃料和原油进行有效的分离。GC×GC与常规和高分辨率质谱联用能够在一次分析中检测和鉴定数百种化合物。基于像素的方法可以有效处理法医和地球化学研究中GC×GC生成的大数据。这篇评论强调了对石油和天然气行业对现代，强大的分析方法的不断增长的需求。在这里，我们描述了石油工业中样品制备，GC×GC仪器和多变量数据分析的最新进展，包括微萃取，高温GC×GC和基于像素的数据分析。