Comparative Metabolomics Elucidates Postprandial Metabolic Modifications in Plasma of Obese Individuals with Metabolic Syndrome,Journal of Proteome Research

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Comparative Metabolomics Elucidates Postprandial Metabolic Modifications in Plasma of Obese Individuals with Metabolic Syndrome
Journal of Proteome Research ( IF 3.8 ) Pub Date : 2018-07-17 , DOI: 10.1021/acs.jproteome.8b00315
Mengyang Xu ₁ , Fanyi Zhong ₁ , Richard S. Bruno ₂ , Kevin D. Ballard ₃ , Jing Zhang ₄ , Jiangjiang Zhu ₁

Affiliation

Although higher intakes of dairy milk are associated with a lower risk of metabolic syndrome (MetS), the underlying protective mechanism remains unclear. This study investigated the dynamic metabolic profile shift following the ingestion of low-fat milk or an isocaloric volume of rice milk in obese individuals with metabolic syndrome (MetS). In a randomized, double-blind, crossover study, postprandial plasma samples (n = 266) were collected from 19 MetS participants. Plasma samples were analyzed by a targeted metabolomics platform which specifically detects 117 metabolites from 25 metabolic pathways. The comprehensive time-course metabolic profiling in MetS participants indicated that the postprandial metabolic profiles distinguish low-fat milk and rice milk consumption in a time-dependent manner. Metabolic biomarkers, such as orotate, leucine/isoleucine and adenine, showed significantly different trends in the two test beverages. Bayesian statistics identified 12 metabolites associated with clinical characteristics of postprandial vascular endothelial function, such as flow-mediated dilation (FMD), postprandial plasma markers of oxidative stress and NO status. Furthermore, metabolic pathway analysis based on these metabolite data indicated the potential utility of metabolomics to provide mechanistic insights of dietary interventions to regulate postprandial metabolic excursions.

中文翻译：

比较代谢组学阐明了肥胖个体代谢综合征的餐后代谢修饰

尽管高摄入量的牛奶与较低的代谢综合征（MetS）风险相关，但其潜在的保护机制仍不清楚。这项研究调查了在患有代谢综合症（MetS）的肥胖个体中，摄入低脂牛奶或等热量的米奶后动态代谢谱变化。在一项随机，双盲，交叉研究中，餐后血浆样本（n= 266）是从19位MetS参与者那里收集的。通过靶向代谢组学平台分析血浆样品，该平台专门从25个代谢途径中检测117种代谢物。MetS参与者的综合时程代谢谱分析表明，餐后代谢曲线以时间依赖的方式区分低脂奶和米奶的摄入量。两种代谢饮料中的代谢生物标志物，例如乳清酸盐，亮氨酸/异亮氨酸和腺嘌呤，显示出明显不同的趋势。贝叶斯统计确定了与餐后血管内皮功能的临床特征相关的12种代谢产物，例如血流介导的扩张（FMD），餐后血浆氧化应激和NO状态标志物。此外，

更新日期：2018-07-18

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