Advanced Silk Fibroin Biomaterials for Cartilage Regeneration,ACS Biomaterials Science & Engineering

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Advanced Silk Fibroin Biomaterials for Cartilage Regeneration
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-07-05 00:00:00 , DOI: 10.1021/acsbiomaterials.8b00150
Gu Cheng _{1,

2} , Zahra Davoudi ₃ , Xin Xing ₁ , Xin Yu ₁ , Xin Cheng ₁ , Zubing Li ₁ , Hongbing Deng ₂ , Qun Wang ₃

Affiliation

Silk fibroin is regarded as a natural fibrous protein with tunable mechanical properties, acceptable biocompatibility, and favorable capability of enhancing attachment, proliferation, and differentiation of chondrocytes. These properties make it suitable for the fabrication of scaffolds and a broad range of silk fibroin-based biomaterials for cartilage regenerative therapy, which can heal functional cartilage without scar tissue. It can be used as a single material for making different kinds of scaffolds or as a composite with other types of biomaterials. Together with some growth factors, silk fibroin scaffolds can form a support for the growth and differentiation of seeding cells, such as chondrogenic lineage cells and mesenchymal stem cells. Recent advancements of silk fibroin in cartilage regeneration are summarized in this review. Furthermore, the manufacturing methods of silk fibroin materials and their applications in the regeneration of cartilage are also discussed.

中文翻译：

先进的丝素蛋白生物材料用于软骨再生

丝素蛋白被认为是天然纤维蛋白，具有可调节的机械性能，可接受的生物相容性以及增强软骨细胞附着，增殖和分化的有利能力。这些特性使其适用于制造支架以及用于软骨再生治疗的多种基于丝素蛋白的生物材料，这些材料可治愈功能性软骨而无疤痕组织。它可以用作制造不同种类支架的单一材料，也可以与其他类型的生物材料复合使用。丝素蛋白支架与一些生长因子一起，可以为诸如软骨生成谱系细胞和间充质干细胞之类的种子细胞的生长和分化提供支持。这篇综述总结了丝素蛋白在软骨再生中的最新进展。此外，

更新日期：2018-07-05

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