Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles†,Organic & Biomolecular Chemistry

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Iron promoted C3–H nitration of 2H-indazole: direct access to 3-nitro-2H-indazoles†
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-07-06 00:00:00 , DOI: 10.1039/c8ob00931g
Arumugavel Murugan _{1,

2,

3} , Koteswar Rao Gorantla _{1,

2,

3} , Bhabani S. Mallik _{1,

2,

3} , Duddu S. Sharada _{1,

2,

3}

Affiliation

An efficient C3–H functionalization of indazole has been demonstrated. Notably, this method involves chelation-free radical C–H nitration on 2H-indazole. The radical mechanism was confirmed by control experiments and quantum chemical calculations. The synthetic utility has been proven by the synthesis of bio-relevant benzimidazoindazoles via reductive cyclization.

中文翻译：

铁促进2 H-吲唑的C3-H硝化：直接获得3-nitro-2 H-吲唑†

吲唑的有效C3–H功能化已得到证明。值得注意的是，该方法涉及在2 H-吲唑上进行螯合自由基C–H硝化。自由基机理已通过控制实验和量子化学计算得到证实。通过还原性环化反应合成生物相关的苯并咪唑并吲哚类化合物已证明了该合成实用性。

更新日期：2018-07-06

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