A protein@metal–organic framework nanocomposite for pH-triggered anticancer drug delivery†,Dalton Transactions

当前位置： X-MOL 学术 › Dalton Trans. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A protein@metal–organic framework nanocomposite for pH-triggered anticancer drug delivery†
Dalton Transactions ( IF 3.5 ) Pub Date : 2018-07-05 00:00:00 , DOI: 10.1039/c8dt01789a
Zuozhong Liang _{1,

2,

3,

4,

5} , Zhiyuan Yang _{1,

2,

3,

4,

5} , Haitao Yuan _{1,

2,

3,

4,

5} , Chun Wang _{6,

7,

8,

9} , Jing Qi _{1,

2,

3,

4,

5} , Kaiqiang Liu _{1,

2,

3,

4,

5} , Rui Cao _{1,

2,

3,

4,

5} , Haoquan Zheng _{1,

2,

3,

4,

5}

Affiliation

We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal–organic framework (MOF) as the shell. Doxorubicin (DOX)/BSA nanoparticles as cores have been prepared. A zeolitic imidazolate framework-8 (ZIF-8) layer has been coated on the outer surface of the DOX/BSA core. The ZIF layer acts as a capsule for the safe storage of DOX under physiological conditions. An efficient pH-responsive drug delivery system using a BSA/DOX@ZIF, in which the drug is not released in PBS at pH 7.4 but is released at low pH (5.0–6.0), has been constructed. Compared to the pure ZIF, a better biocompatibility has been obtained using the BSA/DOX@ZIF. The BSA/DOX@ZIF shows a much higher efficacy than free DOX against the breast cancer cell line MCF-7. The positive charges on the outer surface of the BSA/DOX@ZIF also improve its cellular uptake.

中文翻译：

蛋白质@金属-有机骨架纳米复合材料，用于pH触发的抗癌药物递送†

我们以生物相容性牛血清白蛋白（BSA）为核心，以pH敏感的金属-有机骨架（MOF）为外壳，合成了core @ shell纳米复合材料。已经制备了阿霉素（DOX）/ BSA纳米颗粒作为核心。在DOX / BSA核心的外表面上已涂覆了一个沸石咪唑酸酯骨架8（ZIF-8）层。ZIF层用作在生理条件下安全存储DOX的胶囊。已经构建了使用BSA / DOX @ ZIF的有效的pH响应药物传递系统，其中该药物在pH 7.4时不在PBS中释放，而在低pH值（5.0–6.0）时释放。与纯ZIF相比，使用BSA / DOX @ ZIF获得了更好的生物相容性。BSA / DOX @ ZIF对乳腺癌细胞系MCF-7的功效比游离DOX高得多。

更新日期：2018-07-05

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11