Abstract A simple and highly sensitive approach was performed to synthesize a selective sulfaguanidine (SG) sensor based on a molecularly imprinted electropolymer of acrylamide (PAM) for honey quality control. SG was detected by measurements of electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). These techniques were applied successfully to determine SG with an excellent selectivity when compared to the results of interfering compounds. Furthermore, unprecedented, ultra-low limits of detection (LOD) and quantification (LOQ) of 0.20 pg·mL−1 and 0.67 pg·mL−1, respectively according to DPV measurements and 0.17 pg·mL−1 and 0.57 pg·mL−1 according to EIS measurements. The proposed approach is found to be inexpensive, selective and very sensitive, thanks to the good biocompatibility of SG/PAM composite. The results also showed that this sensor was successfully applied to detect SG residues in honey samples with recoveries between 83.9% and 99.7% and had the potential to be further developed for other multiple analytes detection, thus offering an emerging horizon for bio-sensing applications in honey quality control.

中文翻译：

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用于蜂蜜样品中磺胺胍检测的高灵敏度和选择性分子印迹电化学传感器的开发

摘要 采用一种简单且高灵敏度的方法合成了一种基于丙烯酰胺（PAM）分子印迹电聚合物的选择性磺胺胍（SG）传感器，用于蜂蜜质量控制。通过电化学阻抗谱 (EIS) 和差分脉冲伏安法 (DPV) 的测量检测 SG。与干扰化合物的结果相比，这些技术被成功应用于以优异的选择性测定 SG。此外，根据 DPV 测量值，分别为 0.20 pg·mL-1 和 0.67 pg·mL-1 和 0.17 pg·mL-1 和 0.57 pg·mL 的前所未有的超低检测限 (LOD) 和定量 (LOQ) -1 根据 EIS 测量。由于 SG/PAM 复合材料具有良好的生物相容性，因此发现所提出的方法价格低廉、选择性强且非常灵敏。