Streptococcus suis is an important zoonotic pathogen that causes severe infections and great economic losses worldwide. Understanding how this pathogen senses and responds to environmental signals during the infectious process can offer insight into its pathogenesis and may be helpful in the development of drug targets. Two-component regulatory systems (TCSs) play an essential role in this environmental response. In S. suis, at least 15 groups of TCSs have been predicted. Among them, several have been demonstrated to be involved in virulence and/or stress response. In this review, we discuss the progress in the study of TCSs in S. suis, focusing on the role of these systems in the virulence of this bacterium.

猪链球菌是一种重要的人畜共患病原体，在世界范围内引起严重的感染和巨大的经济损失。了解这种病原体在传染过程中如何感知和响应环境信号可以提供其发病机理的见解，并可能有助于开发药物靶标。两部分的监管体系（TCS）在这种环境响应中起着至关重要的作用。在猪链球菌中，已经预测到至少有15组TCS。其中，已证明其中几种涉及毒力和/或应激反应。在这篇综述中，我们讨论了猪链球菌TCS的研究进展，重点是这些系统在这种细菌的毒性中的作用。