Nanofibrillar Patches of Commensal Skin Bacteria.,Biomacromolecules

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Nanofibrillar Patches of Commensal Skin Bacteria.
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-07-19 , DOI: 10.1021/acs.biomac.8b00735
Karine Glinel _{1,

2} , Adam Behrens ₂ , Robert S Langer ₂ , Ana Jaklenec ₂ , Alain M Jonas _{1,

2}

Affiliation

We demonstrate entrapment of the commensal skin bacteria Staphylococcus epidermidis in mats composed of soft nanotubes made by membrane-templated layer-by-layer (LbL) assembly. When cultured in broth, the resulting nanofibrillar patches efficiently delay the escape of bacteria and their planktonic growth, while displaying high steady-state metabolic activity. Additionally, the material properties and metabolic activity can be further tuned by postprocessing the patches with additional polysaccharide LbL layers. These patches offer a promising methodology for the fabrication of bacterial skin dressings for the treatment of skin dysbiosis while preventing adverse effects due to bacterial proliferation.

中文翻译：

常见皮肤细菌的纳米原纤维斑块。

我们证明了由皮肤软化的纳米管组成的膜中的共生皮肤细菌表皮葡萄球菌的包裹，该软纳米管由膜模板化的逐层（LbL）组装而成。当在肉汤中培养时，所得的纳米原纤维斑块有效地延迟了细菌的逸出及其浮游生物的生长，同时表现出高的稳态代谢活性。另外，可以通过用额外的多糖LbL层对贴片进行后处理来进一步调整材料特性和代谢活性。这些贴剂为制造用于治疗皮肤病的细菌皮肤敷料提供了一种有前途的方法，同时可以防止由于细菌繁殖引起的不良影响。

更新日期：2018-07-06

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