Udder cleft dermatitis (UCD) is a skin lesion in dairy cows affecting the anterior parts of the udder, with the lesions often needing a long time to heal. The lesions can be characterized as mild or severe. The etiology of UCD is not fully understood and studies on the effectiveness of topical treatments have not been published. The objective of this study, therefore, was to conduct a randomized clinical trial to investigate the effectiveness of 2 different topical treatments, one for mild and one for severe UCD lesions, compared with untreated control groups. The treatment and control groups were randomized within herd for mild and severe UCD. The treatments were applied for a maximum period of 12 wk on 8 Dutch dairy farms. Mild UCD lesions were treated once a d 3 times a week on fixed days with a non-sting barrier film. Severe UCD lesions were first stratified into class A (lesion length <5 cm) or class B (lesion length ≥5 cm) and then randomly allocated to treatment or control groups within herd. Both severe lesion classes were treated once per day every day with an enzyme alginogel. Every week, the lesions of affected animals were inspected and photographed by the investigator. These photographs were reviewed weekly by an external wound expert who classified the lesions as mild, severe class A, severe class B, or healed. Based on this classification, the investigator judged weekly whether the lesions had improved compared with their classification of the previous week. For mild UCD lesions, improvement was defined as occurring when lesions were healed. For severe UCD lesions, improvement was defined as a transition from class B to class A, transition from any severe UCD lesion (class A or B) to a mild UCD lesion, or when the lesion was defined as healed. Data were analyzed using a discrete time survival analysis with time to first improvement as dependent variable. In total, data from 214 animals were analyzed to estimate the effectiveness of treatment. Results showed that treatment of mild UCD lesions had no influence on improvement compared with untreated lesions. Treated severe lesions, however, showed 3.4 times more improvement compared with the untreated controls. Improvement varied between herds, and cows with a parity of 5 or higher showed significantly less improvement than first parity animals. Early identification of severe UCD lesions followed by prompt treatment with an enzyme alginogel supports the healing process.

乳房c裂性皮炎（UCD）是奶牛的皮肤病变，会影响乳房的前部，病变通常需要很长时间才能治愈。病变的特征可以是轻度或重度。UCD的病因尚未完全了解，局部治疗有效性的研究尚未发表。因此，本研究的目的是进行一项随机临床试验，以研究与未治疗的对照组相比，两种不同的局部治疗方法的有效性，一种用于轻度治疗，一种用于严重UCD病变治疗。治疗组和对照组在牛群中随机分为轻度和重度UCD。在8个荷兰奶牛场上，这些处理的最长施用期为12周。轻度的UCD病变在固定的日子每周3次，每次3次，并用防刺破膜处理。严重的UCD病变首先被分为A级（病变长度<5 cm）或B级（病变长度≥5cm），然后随机分配到治疗组或对照组。每天使用酶藻胶治疗两种严重病变类型，每天一次。每周，研究人员都要检查并给患病动物的病变拍照。外部伤口专家每周对这些照片进行检查，他们将病变分为轻度，严重A级，严重B级或已治愈。根据此分类，研究人员每周判断病变与前一周的分类相比是否有所改善。对于轻度的UCD病变，定义为在病变愈合时发生改善。对于严重的UCD病变，改善定义为从B级到A级的过渡，从任何严重的UCD病变（A或B类）转变为轻度的UCD病变，或当病变被定义为已治愈时。使用离散时间生存分析对数据进行分析，其中首次改进时间为因变量。总共对来自214只动物的数据进行了分析，以评估治疗的有效性。结果表明，与未治疗的病变相比，轻度UCD病变的治疗对改善无影响。然而，与未治疗的对照组相比，治疗后的严重病变显示出3.4倍的改善。牛群之间的改善程度各不相同，而胎龄为5或更高的母牛表现出的改善要明显少于第一胎的动物。尽早识别出严重的UCD病变，然后立即用酶藻胶进行治疗可支持愈合过程。或病变定义为已治愈时。使用离散时间生存分析对数据进行分析，其中首次改进时间为因变量。总共对来自214只动物的数据进行了分析，以评估治疗的有效性。结果表明，与未治疗的病变相比，轻度UCD病变的治疗对改善无影响。然而，与未治疗的对照组相比，治疗后的严重病变显示出3.4倍的改善。牛群之间的改善程度各不相同，而胎龄为5或更高的母牛表现出的改善要明显少于第一胎的动物。尽早识别出严重的UCD病变，然后立即用酶藻胶进行治疗可支持愈合过程。或病变定义为已治愈时。使用离散时间生存分析对数据进行分析，其中首次改进时间为因变量。总共对来自214只动物的数据进行了分析，以评估治疗的有效性。结果表明，与未治疗的病变相比，轻度UCD病变的治疗对改善无影响。然而，与未治疗的对照组相比，治疗后的严重病变显示出3.4倍的改善。牛群之间的改善程度各不相同，而胎龄为5或更高的母牛表现出的改善要明显少于第一胎的动物。尽早识别出严重的UCD病变，然后立即用酶藻胶进行治疗可支持愈合过程。使用离散时间生存分析对数据进行分析，其中首次改进时间为因变量。总共对来自214只动物的数据进行了分析，以评估治疗的有效性。结果表明，与未治疗的病变相比，轻度UCD病变的治疗对改善无影响。然而，与未治疗的对照组相比，治疗后的严重病变显示出3.4倍的改善。牛群之间的改善程度各不相同，而胎龄为5或更高的母牛表现出的改善要明显少于第一胎的动物。尽早识别出严重的UCD病变，然后立即用酶藻胶进行治疗可支持愈合过程。使用离散时间生存分析对数据进行分析，其中首次改进时间为因变量。总共对来自214只动物的数据进行了分析，以评估治疗的有效性。结果表明，与未治疗的病变相比，轻度UCD病变的治疗对改善无影响。然而，与未治疗的对照组相比，治疗后的严重病变显示出3.4倍的改善。牛群之间的改善程度各不相同，而胎龄为5或更高的母牛表现出的改善要明显少于第一胎的动物。尽早识别出严重的UCD病变，然后立即用酶藻胶进行治疗可支持愈合过程。结果表明，与未治疗的病变相比，轻度UCD病变的治疗对改善无影响。然而，与未治疗的对照组相比，治疗后的严重病变显示出3.4倍的改善。牛群之间的改善程度各不相同，而胎龄为5或更高的母牛表现出的改善要明显少于第一胎的动物。尽早识别出严重的UCD病变，然后立即用酶藻胶进行治疗可支持愈合过程。结果表明，与未治疗的病变相比，轻度UCD病变的治疗对改善无影响。然而，与未治疗的对照组相比，治疗后的严重病变显示出3.4倍的改善。牛群之间的改善程度各不相同，而胎龄为5或更高的母牛表现出的改善要明显少于第一胎的动物。尽早识别出严重的UCD病变，然后立即用酶藻胶进行治疗可支持愈合过程。