Three new itaconic acid derivatives, asperitaconic acids A-C (1-3), were isolated from the ethyl acetate extracts of the rice fermentation of a marine-derived fungus Aspergillus niger, and asperitaconic acids A-C were characterized by an itaconic acid unit and an alkyl chain moiety. Their structures were established by interpretation of their spectroscopic data including NMR and HRESIMS. Asperitaconic acids A-C exhibited antibacterial effect against Staphylococcus aureus with MIC values of 16-32 μg/mL, whereas these compounds showed no cytotoxicity against HepG2 and HeLa cancer cell lines.

中文翻译：

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Asperitaconic酸AC，由曲霉属的海洋衍生真菌产生的抗菌衣康酸衍生物。

从海生真菌黑曲霉的大米发酵的乙酸乙酯提取物中分离出三种新的衣康酸衍生物，曲康康酸AC（1-3），并通过衣康酸单元和烷基链表征了曲康康酸AC部分。通过解释其光谱数据（包括NMR和HRESIMS）来确定其结构。曲霉烯酸AC对金黄色葡萄球菌具有抗菌作用，MIC值为16-32μg/ mL，而这些化合物对HepG2和HeLa癌细胞系均无细胞毒性。