Five new peptides, Sinulariapeptides A-E together with seven known peptides (6-12) were isolated from the soft coral associated fungus Simplicillium sp. SCSIO 41209. The structures of the new compounds and their absolute configurations were established on the basis of spectroscopic analysis including NMR, MS and ECD. All the Compounds (except sinulariapeptides B-D) were tested for the inhibitory activities of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), and antifungal activities against five plant pathogenic fungi. Simplicilliumtides B and cyclo(L-Val-L-Pro) showed inhibitory activity with the IC50 values of 35.0 and 25.9 μM, sinulariapeptides A, simplicilliumtides J, verlamelins A and B exhibited potent inhibition against Colletotrichum asianum with the MIC values of range from 4.9 to 9.8 μg/mL and simplicilliumtides J, verlamelins A and B displayed inhibition against Pyricularia oryza Cav with the MIC values in the range of 19.5-78.1 μg/ml, respectively.

中文翻译：

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来自软珊瑚相关真菌 Simplicillium sp. 的肽。SCSIO41209

从软珊瑚相关真菌 Simplicillium sp. 中分离出五种新肽、Sinulariape​​ptides AE 和七种已知肽 (6-12)。SCSIO 41209。新化合物的结构及其绝对构型建立在光谱分析的基础上，包括NMR、MS和ECD。测试了所有化合物（除了sinulariape​​ptides BD）的结核分枝杆菌蛋白酪氨酸磷酸酶B（MptpB）的抑制活性和对五种植物病原真菌的抗真菌活性。Simplicilliumtides B 和 cyclo(L-Val-L-Pro) 显示出抑制活性，IC50 值为 35.0 和 25.9 μM，sinulariape​​ptides A、simplicilliumtides J、verlamelins A 和 B 显示出对 Colletotrichum asianum 的有效抑制，MIC 值为 4.9。至 9.8 μg/mL 和 simplicilliumtides J，