A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air†,Organic Chemistry Frontiers

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A facile synthesis of diverse 5-arylated triazoles via a Cu-catalyzed oxidative interrupted click reaction with arylboronic acids in air†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-07-04 00:00:00 , DOI: 10.1039/c8qo00590g
Xiaoxia Yu _{1,

2,

3,

4,

5} , Jian Xu _{1,

2,

3} , Yao Zhou _{1,

2,

3} , Qiuling Song _{1,

2,

3}

Affiliation

We herein disclose a Cu-catalyzed synthesis of 5-arylsubstituted 1,2,3-triazoles via an oxidative interrupted click reaction, using air as the sole terminal oxidant. The current protocol provides a novel method for the one-step construction of fully substituted triazoles in good yields under mild conditions, in which arylboronic acids are employed as aromatic sources to interrupt the cuprate–triazole intermediate for the first time.

中文翻译：

多样5-芳基化的三唑的简便合成通过与空气中的芳基硼酸的Cu-催化氧化中断点击反应†

我们在此公开了使用空气作为唯一的末端氧化剂，通过氧化间断的点击反应的Cu催化的5-芳基取代的1,2,3-三唑的合成。目前的方案为在温和条件下以高收率单步构建完全取代的三唑提供了一种新颖的方法，其中芳基硼酸被用作芳烃来源，首次中断了铜酸盐-三唑中间体。

更新日期：2018-07-04

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