C–H alkylation reactions of indoles mediated by Pd(ii) and norbornene: applications and recent developments,Organic & Biomolecular Chemistry

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C–H alkylation reactions of indoles mediated by Pd(ii) and norbornene: applications and recent developments
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-07-04 00:00:00 , DOI: 10.1039/c8ob01025k
Marcus Wegmann _{1,

2,

3,

4} , Michael Henkel _{1,

2,

3,

4} , Thorsten Bach _{1,

2,

3,

4}

Affiliation

The Catellani reaction enables an ortho-C–H activation based on oxidative addition of Pd(0) and an intermediary carbopalladation of norbornene. Among its variants, the recently developed C2-selective alkylation of indoles is particular as it employs Pd(II) as the source of palladium. This review describes the mechanistic background of this transformation. Applications in total synthesis and in the synthesis of biologically relevant molecules are illustrated and further developments of the method are discussed.

中文翻译：

Pd（ii）和降冰片烯介导的吲哚的CH烷基化反应：应用和最新进展

卡特兰尼反应可基于Pd（0）的氧化加成和降冰片烯的中间碳钯反应使邻位C-H活化。在其变体中，最近开发的吲哚的C 2-选择性烷基化是特别的，因为其使用Pd（II）作为钯的来源。这篇评论描述了这种转变的机理背景。说明了在全合成和生物学相关分子合成中的应用，并讨论了该方法的进一步发展。

更新日期：2018-07-04

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