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Changing environments and biomolecule coronas: consequences and challenges for the design of environmentally acceptable engineered nanoparticles
Green Chemistry ( IF 9.3 ) Pub Date : 2018-07-04 , DOI: 10.1039/c8gc01171k Marta Markiewicz 1, 2, 3, 4, 5 , Jolanta Kumirska 6, 7, 8, 9, 10 , Iseult Lynch 11, 12, 13, 14, 15 , Marianne Matzke 15, 16, 17 , Jan Köser 1, 2, 3, 4 , Steve Bemowsky 1, 2, 3, 4 , Dominic Docter 4, 18, 19, 20 , Roland Stauber 4, 18, 19, 20 , Dana Westmeier 4, 18, 19, 20 , Stefan Stolte 1, 2, 3, 4, 5
Green Chemistry ( IF 9.3 ) Pub Date : 2018-07-04 , DOI: 10.1039/c8gc01171k Marta Markiewicz 1, 2, 3, 4, 5 , Jolanta Kumirska 6, 7, 8, 9, 10 , Iseult Lynch 11, 12, 13, 14, 15 , Marianne Matzke 15, 16, 17 , Jan Köser 1, 2, 3, 4 , Steve Bemowsky 1, 2, 3, 4 , Dominic Docter 4, 18, 19, 20 , Roland Stauber 4, 18, 19, 20 , Dana Westmeier 4, 18, 19, 20 , Stefan Stolte 1, 2, 3, 4, 5
Affiliation
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Nanomaterials (NMs) are gaining increasing commercial importance due to a variety of properties that cannot be achieved with bulk materials. Yet the assessment of their environmental impacts lags behind the technological development. First attempts towards designing inherently safer NMs have been made, yet we are still unable to formulate rules of green nano-design, especially in terms of mitigating (long-term) toxicity and bioaccumulation. Importantly, NMs released to the environment acquire a so called ‘environmental corona’ – a complex layer of spontaneously adsorbed biomolecules – that significantly impacts their behaviour and fate. This review integrates the current literature on the impact of environmental conditions on NMs fate and behaviour, including corona formation, colloidal stability, reactivity, and toxicty, using a broad range of environmentally relevant NMs. Collectively, components of natural waters (such as salts and/or natural organic matter) often mitigate negative impacts of NMs via different mechanisms including surface passivation and stabilisation against dissolution. The review concludes by discussing some initial strategies on how to rationally design more environmentally acceptable NMs.
中文翻译：
不断变化的环境和生物分子电晕：环境可接受的工程纳米粒子设计的后果和挑战
由于散装材料无法实现的各种特性，纳米材料（NMs）在商业上正变得越来越重要。然而，对其环境影响的评估仍落后于技术发展。已经进行了设计本质上更安全的NM的首次尝试，但是我们仍然无法制定绿色纳米设计的规则，特别是在减轻（长期）毒性和生物蓄积方面。重要的是，释放到环境中的NMs会获得所谓的“环境电晕”（即自发吸附的生物分子的复杂层），从而极大地影响其行为和命运。这篇评论综合了有关环境条件对NMs命运和行为影响的最新文献，包括电晕形成，胶体稳定性，反应性和毒性，使用范围广泛的与环境相关的NM。总的来说，天然水的成分（例如盐和/或天然有机物）通常可以减轻NM的负面影响通过不同的机制，包括表面钝化和稳定溶解。回顾通过讨论一些有关如何合理设计更环境可接受的NM的初步策略来结束。
更新日期：2018-09-17
中文翻译：
不断变化的环境和生物分子电晕：环境可接受的工程纳米粒子设计的后果和挑战
由于散装材料无法实现的各种特性，纳米材料（NMs）在商业上正变得越来越重要。然而，对其环境影响的评估仍落后于技术发展。已经进行了设计本质上更安全的NM的首次尝试，但是我们仍然无法制定绿色纳米设计的规则，特别是在减轻（长期）毒性和生物蓄积方面。重要的是，释放到环境中的NMs会获得所谓的“环境电晕”（即自发吸附的生物分子的复杂层），从而极大地影响其行为和命运。这篇评论综合了有关环境条件对NMs命运和行为影响的最新文献，包括电晕形成，胶体稳定性，反应性和毒性，使用范围广泛的与环境相关的NM。总的来说，天然水的成分（例如盐和/或天然有机物）通常可以减轻NM的负面影响通过不同的机制，包括表面钝化和稳定溶解。回顾通过讨论一些有关如何合理设计更环境可接受的NM的初步策略来结束。
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