A fast and simple supercritical fluid chromatography method for the enantioseparation of twenty newly synthesized orthoconic antiferroelectric liquid crystals is reported for the first time. The effects of alkoxy spacer length and fluorine atom presence and position in the phenyl ring on chromatographic behavior were investigated. Baseline enantioseparation of all compounds was achieved using simple mobile phases consisting of carbon dioxide and alcohol as cosolvent on (3,5-dimethylphenylcarbamate) derivative of amylose as chiral stationary phase. The analysis times ranged from 2 to 4 and from 4 to 7 min for most samples when using methanol and propane-2-ol, respectively. The significant effect of cosolvent type on the enantioseparation of these compounds was assessed and partial complementarity of methanol and propane-2-ol was observed.

中文翻译：

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超高效超临界流体色谱：热致氟化液晶对映分离的强大工具

首次报道了一种快速简便的超临界流体色谱法，用于对二十种新合成的正交反铁电液晶进行对映分离。研究了烷氧基间隔长度和氟原子的存在和苯环中的位置对色谱行为的影响。所有化合物的基线对映分离是使用简单的流动相实现的，该流动相由二氧化碳和酒精组成，作为手性固定相的直链淀粉（3,5-二甲基苯基氨基甲酸酯）衍生物的共溶剂。当分别使用甲醇和丙烷-2-醇时，大多数样品的分析时间范围分别为 2 到 4 分钟和 4 到 7 分钟。评估了共溶剂类型对这些化合物的对映分离的显着影响，并观察到甲醇和丙烷-2-醇的部分互补性。