Parabens have been widely used as antimicrobial preservatives in food, drugs, and cosmetics for over 60 years. These endocrine disruptors can alter both the wildlife and the human hormone function. Determining these compounds in human milk is important because breast milk plays an important role in infant growth and in neurocognitive development. This article summarizes the current state-of-the-art of chromatographic methods to determine parabens in breast milk samples. Apart from the conventional and modern microextraction sample preparation techniques described herein, the authors discuss the chromatographic systems, primarily LC-MS/MS, and the concentration ranges at which parabens have been detected in milk samples obtained from lactating women over the past few years.

对羟基苯甲酸酯已被广泛用作食品，药品和化妆品中的抗菌防腐剂，已有60多年的历史了。这些内分泌干扰物可以改变野生动植物和人类荷尔蒙的功能。确定母乳中的这些化合物很重要，因为母乳在婴儿生长和神经认知发育中起着重要作用。本文概述了测定母乳样品中对羟基苯甲酸酯的最新色谱方法。除了本文所述的常规和现代微萃取样品制备技术外，作者还讨论了色谱系统（主要是LC-MS / MS）以及在过去几年中从哺乳期妇女获得的牛奶样品中检测到对羟基苯甲酸酯的浓度范围。