The new multicomponent reaction has been found: the pyridine or triethylamine catalyzed multicomponent transformation of salicylaldehydes, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and 3-trifluoromethyl-2-pyrazolin-5-one results in efficient formation of the earlier unknown substituted 2,4-diamino-5-[5-hydroxy-3-(trifluoromethyl)-1H-pyrazol-4-yl]-5H-chromeno[2,3-b]pyridine-3-carbonitriles in 58–92% yields. This new process opens a facile and efficient way to the new type of functionalized 5-C-substituted 2,4-diamino-5H-chromeno[2,3-b]pyridine scaffold, containing the 3-trifluoromethyl-2-pyrazolin-5-one fragment, which are promising compounds for different biomedical applications.

已发现新的多组分反应：吡啶或三乙胺催化的水杨醛，2-氨基丙-1-烯-1,1,3-三腈和3-三氟甲基-2-吡唑啉-5-酮的多组分转化可有效形成较早的未知取代的2,4-二氨基-5- [5-羟基-3-（三氟甲基）-1 H-吡唑-4-基] -5 H-苯并[2,3 - b ]吡啶-3-甲腈58–92％的产量。此新方法为新型功能化的5-C-取代的2,4-二氨基-5 H -chromeno [2,3- b ]吡啶骨架（包含3-三氟甲基-2-吡唑啉- 5-one片段，是用于不同生物医学应用的有前途的化合物。