High chromium yeast has attracted many researchers for its high efficiency and high safety among chromium supplements. The preventive effect of oral high-chromium yeast on diabetes was assessed using KK-AY mice. Sixteen-wk-old type 2 diabetic KK-AY mice were divided into five groups and orally administered with two types of drying processed high-chromium yeast, chromium picolinate at 1000 μg Cr/kg/d, metformin (positive control), and normal yeast (negative control) for 13 weeks. The spray-dried high-chromium yeast significantly delayed the onset of hyperglycemia in type 2 diabetic KK-AY mice (P < 0.05) and significantly improved fasting blood glucose, TG(triglyceride), and TCHO(total cholesterol) . Histopathological analysis showed that the spray-dried high-chromium yeast led to high affinities for the stains to the β-cells in the islets of Langerhans and alleviated hepatic steatosis. High-chromium yeast could be a potential candidate for nutritional supplement to ameliorate diabetes. PRACTICAL APPLICATION Chromium plays an important role in fat and carbohydrate metabolism. The result show that spray-dried high chromium yeast significantly delayed the onset of hyperglycemia in type 2 diabetic KK-AY mice. As one of chromium supplements, the purpose of this study is to examine the efficacy of high chromium yeast on the type 2 diabetes and drying method on its bioactivity, which will be useful for research and development of high-chromium yeast and improvement of pharmacological activity-based quality control.

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高铬酵母对 2 型糖尿病 KK-Ay 小鼠的抗糖尿病作用

高铬酵母在铬补充剂中以其高效率和高安全性吸引了众多研究人员。使用KK-AY小鼠评估口服高铬酵母对糖尿病的预防作用。将 16 周龄 2 型糖尿病 KK-AY 小鼠分为 5 组，分别口服两种干燥处理的高铬酵母、1000 μg Cr/kg/d 的吡啶甲酸铬、二甲双胍（阳性对照）和正常酵母（阴性对照）13 周。喷雾干燥的高铬酵母显着延迟了 2 型糖尿病 KK-AY 小鼠的高血糖发作（P < 0.05），并显着改善了空腹血糖、TG（甘油三酯）和 TCHO（总胆固醇）。组织病理学分析表明，喷雾干燥的高铬酵母使染色剂对朗格汉斯胰岛中的β细胞具有高亲和力，并减轻了肝脏脂肪变性。高铬酵母可能是改善糖尿病的营养补充剂的潜在候选者。实际应用铬在脂肪和碳水化合物代谢中起重要作用。结果表明，喷雾干燥的高铬酵母显着延缓了 2 型糖尿病 KK-AY 小鼠的高血糖发作。本研究作为铬补充剂之一，旨在考察高铬酵母对2型糖尿病的疗效及干燥法对其生物活性的影响，为高铬酵母的研发和药理活性的提高提供参考。 - 基于质量控制。