Aggregation‐Induced Emission Luminogens: Union Is Strength, Gathering Illuminates Healthcare,Advanced Healthcare Materials

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Aggregation‐Induced Emission Luminogens: Union Is Strength, Gathering Illuminates Healthcare
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-07-03 , DOI: 10.1002/adhm.201800477
Ji Qi ₁ , Chao Chen ₂ , Dan Ding ₂ , Ben Zhong Tang _{1,

3}

Affiliation

The rapid development of healthcare techniques encourages the emergence of new molecular imaging agents and modalities. Fluorescence imaging that enables precise monitoring and detection of biological processes/diseases is extensively investigated as this imaging technique has strengths in terms of high sensitivity, excellent temporal resolution, low cost, and good safety. Aggregation‐induced emission luminogens (AIEgens) have recently emerged as a new class of emitters that possess several notable features, such as high brightness, large Stokes shift, marked photostability, good biocompatibility, and so on. So far, AIEgens are widely explored and exhibit superb performance in the area of biomedicine and life sciences. Herein, this review summarizes and discusses the recent investigations of AIEgens for in vivo diagnosis and therapy including long‐term tracking, 3D angiography, multimodality imaging, disease theranostics, and activatable sensing. Collectively, these results reveal that AIEgens are of great promise for in vivo biomedical applications. It is hoped that this review will lead to new insights into the development of advanced healthcare materials.

中文翻译：

聚集引起的发光源：团结就是力量，聚集起来照亮了医疗保健

医疗保健技术的飞速发展鼓励了新的分子显像剂和新形式的出现。由于这种成像技术在高灵敏度，出色的时间分辨率，低成本和良好的安全性方面具有优势，因此广泛地研究了能够精确监控和检测生物过程/疾病的荧光成像。聚集诱导的发光致发光剂（AIEgens）最近作为一种新型的发光体出现了，它具有几个显着的特征，例如高亮度，大斯托克斯位移，显着的光稳定性，良好的生物相容性等。迄今为止，在生物医学和生命科学领域，AIEgens已被广泛探索并表现出卓越的性能。在此处，这篇综述总结并讨论了AIEgens在体内诊断和治疗方面的最新研究，包括长期跟踪，3D血管造影，多模态成像，疾病诊断学和可激活的传感。总体而言，这些结果表明，AIEgens对于体内生物医学应用具有广阔的前景。希望这次审查将对先进的医疗保健材料的开发产生新的见解。

更新日期：2018-07-03

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