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Cu(II)-Catalyzed Ortho-C–H Nitration of Aryl Ureas By C–H Functionalization
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-07-03 00:00:00 , DOI: 10.1021/acs.joc.8b01016
Chun-Meng Wang 1 , Kai-Xiang Tang 1 , Tian-Hong Gao 1 , Lin Chen 1 , Li-Ping Sun 1
Affiliation  

A novel protocol for the aromatic ortho C–H nitration of aryl ureas with Fe(NO3)3·9H2O is developed. The reaction utilizes CuCl2·2H2O as catalyst and p-TSA as additive, showing good functional group tolerance and furnishing the desired products in moderate to excellent yields.

中文翻译:

Cu(II)通过C–H官能化催化芳基尿素的邻位–C–H硝化

提出了一种用Fe(NO 33 ·9H 2 O芳基尿素的芳族邻位碳氢硝化的新方案。该反应使用CuCl 2 ·2H 2 O作为催化剂,使用p -TSA作为添加剂,显示出良好的官能团耐受性,并以中等至极好的收率提供了所需的产物。
更新日期:2018-07-03
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