Three-Component Reactions of Arynes, Amines, and Nucleophiles via a One-Pot Process,The Journal of Organic Chemistry

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Three-Component Reactions of Arynes, Amines, and Nucleophiles via a One-Pot Process
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-07-03 00:00:00 , DOI: 10.1021/acs.joc.8b01058
Gyoungwook Min ₁ , Jeongseob Seo ₁ , Haye Min Ko ₁

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An unprecedented three-component reaction of arynes, tertiary amines, and nucleophiles has been demonstrated through ammonium salt intermediates. This protocol allows access to tertiary aniline derivatives containing the piperazine motif in good-to-excellent yields. Expansively, this reaction can produce biologically important 2-(4-phenylpiperazin-1-yl)ethyl-containing molecules using arynes, 1,4-diazabicyclo(2.2.2)octane (DABCO), and nucleophiles via a one-pot process.

中文翻译：

一锅法进行的芳烃，胺和亲核试剂的三组分反应

通过铵盐中间体已证明了芳烃，叔胺和亲核试剂的前所未有的三组分反应。该方案允许以良好至优异的产率获得含有哌嗪基序的叔苯胺衍生物。广泛地，该反应可以通过一锅法使用芳烃，1,4-二氮杂双环（2.2.2）辛烷（DABCO）和亲核试剂产生具有生物学重要性的含2-（4-苯基哌嗪-1-基）乙基的分子。

更新日期：2018-07-03

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