Transition-Metal-Free Approach for the Synthesis of 4-Aryl-quinolines from Alkynes and Anilines,The Journal of Organic Chemistry

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Transition-Metal-Free Approach for the Synthesis of 4-Aryl-quinolines from Alkynes and Anilines
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-07-03 00:00:00 , DOI: 10.1021/acs.joc.8b01204
Mandalaparthi Phanindrudu _{1,

2} , Sandip Balasaheb Wakade _{1,

2} , Dipak Kumar Tiwari _{1,

2} , Pravin R. Likhar _{2,

3} , Dharmendra Kumar Tiwari _{1,

2}

Affiliation

An efficient and transition-metal-free approach for the synthesis of 4-arylquinolines from readily available anilines and alkynes in the presence of K₂S₂O₈ and DMSO has been developed. A variety of alkynes and anilines having a diverse range of substitution patterns can undergo the one-pot cascade process successfully. Effectively, this method uses DMSO as one carbon source, thus providing a highly atom-economical and environmentally benign approach for the synthesis of 4-arylquinolines.

中文翻译：

由炔烃和苯胺合成4-芳基喹啉的无过渡金属方法

在K ₂ S ₂ O ₈和DMSO存在下，由苯胺和炔烃合成4-芳基喹啉的有效且无过渡金属的方法已得到开发。具有不同取代模式范围的各种炔烃和苯胺可以成功地经历一锅级联过程。有效地，该方法使用DMSO作为一种碳源，从而为合成4-芳基喹啉提供了一种极富原子经济性和环境友好性的方法。

更新日期：2018-07-03

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