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Room temperature dehalogenation of (hetero)aryl halides with magnesium/methanol
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-07-04 , DOI: 10.1016/j.tetlet.2018.07.008
Jabrane Jouha , Mostafa Khouili , Marie-Aude Hiebel , Gérald Guillaumet , Franck Suzenet

Magnesium in methanol was found to be an effective and inexpensive reagent for the dehalogenation of (hetero)aryl chlorides, bromides and iodides under mild conditions. The halogen/hydrogen exchange proceeded at room temperature and tolerated functional groups such as esters, nitriles, alcohols, and alkenes.



中文翻译:

(杂)芳基卤化物在室温下用镁/甲醇进行脱卤

发现甲醇中的镁是在温和条件下对(杂)芳基氯化物,溴化物和碘化物进行脱卤作用的有效且廉价的试剂。卤素/氢交换是在室温下进行的,并具有可耐受的官能团,例如酯,腈,醇和烯烃。

更新日期:2018-07-04
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