Abstract

The synthesis of pharmacologically relevant scaffolds is an important goal in modern organic chemistry. For this reason, the use of methodologies involving operationally simple procedures and easily handled reagents to chemoselectively and stereoselectively convert different functionalities has gained considerable attention. In this review, we summarize the latest trends in reductive reactions using triethyl­silane as the key reagent that provide synthetically interesting intermediates, coupling products and structures with control of the 3D architecture.

1 Introduction

2 Scenario A: Reduction of C–C Multiple Bonds

3 Scenario B: Reduction of Functional Groups

4 Scenario C: Reductive Coupling

5 Scenario D: Reductive Cyclization

6 Conclusion

The synthesis of pharmacologically relevant scaffolds is an important goal in modern organic chemistry. For this reason, the use of methodologies involving operationally simple procedures and easily handled reagents to chemoselectively and stereoselectively convert different functionalities has gained considerable attention. In this review, we summarize the latest trends in reductive reactions using triethyl­silane as the key reagent that provide synthetically interesting intermediates, coupling products and structures with control of the 3D architecture.

1 Introduction

2 Scenario A: Reduction of C–C Multiple Bonds

3 Scenario B: Reduction of Functional Groups

4 Scenario C: Reductive Coupling

5 Scenario D: Reductive Cyclization

6 Conclusion

中文翻译：

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三乙基硅烷在有机合成中的应用进展

摘要

药理学相关支架的合成是现代有机化学的重要目标。由于这个原因，使用涉及操作简单的程序和易于处理的试剂的方法来化学选择性和立体选择性地转换不同的功能已经引起了相当大的关注。在本综述中，我们总结了使用三乙基硅烷作为关键试剂的还原反应的最新趋势，该试剂提供了合成有趣的中间体，可控制3D结构的偶联产物和结构。

1引言

2种情况A：减少C–C多重键

3方案B：减少功能组

4方案C：还原耦合

5方案D：还原环化

六，结论

药理学相关支架的合成是现代有机化学的重要目标。由于这个原因，使用涉及操作简单的程序和易于处理的试剂的方法来化学选择性和立体选择性地转换不同的功能已经引起了相当大的关注。在本综述中，我们总结了使用三乙基硅烷作为关键试剂的还原反应的最新趋势，该试剂提供了合成有趣的中间体，可控制3D结构的偶联产物和结构。

1引言

2种情况A：减少C–C多重键

3方案B：减少功能组

4方案C：还原耦合

5方案D：还原环化

六，结论