Rational drug design method has been used to generate 4-arylpiperazine carboxamides in an effort to develop safer, more potent and effective monoamine neurotransmitters reuptake inhibitors. Out of twenty-seven synthesized compounds, compound 9 displayed potent monoamine neurotransmitter reuptake inhibitory activity against HEK cells transfected with hSERT or hNET. A Surflex-Dock docking model of 9 was also studied.

中文翻译：

---

设计，合成和对接研究4-芳基哌嗪羧酰胺作为单胺类神经递质再摄取抑制剂

合理的药物设计方法已用于产生4-芳基哌嗪羧酰胺，以开发更安全，更有效的单胺神经递质再摄取抑制剂。在27种合成化合物中，化合物9对转染了hSERT或hNET的HEK细胞显示出有效的单胺神经递质再摄取抑制活性。还研究了9的Surflex-Dock对接模型。