In situ fluorescence monitoring of diagnosis and treatment: a versatile nanoprobe combining tumor targeting based on MUC1 and controllable DOX release by telomerase†,Chemical Communications

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In situ fluorescence monitoring of diagnosis and treatment: a versatile nanoprobe combining tumor targeting based on MUC1 and controllable DOX release by telomerase†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-07-02 00:00:00 , DOI: 10.1039/c8cc05052j
Haibin Si _{1,

2,

3,

4,

5} , Lijuan Wang _{1,

2,

3,

4,

5} , Qingling Li _{1,

2,

3,

4,

5} , Xiaoxiao Li _{1,

2,

3,

4,

5} , Lu Li _{1,

2,

3,

4,

5} , Bo Tang _{1,

2,

3,

4,

5}

Affiliation

We have constructed versatile drug-loaded nanoprobes capable of responding to both MUC1 and telomerase and achieving intracellular drug release. Besides, the synthesized drug-loaded nanoprobes can realize the in situ imaging observation of the whole process of nanoprobes targeting the tumor cell membrane, the transmembrane entering the cytoplasm and the release of DOX into the cell nucleus.

中文翻译：

原位荧光监测的诊断和治疗：多功能纳米探针，结合基于MUC1的肿瘤靶向和端粒酶可控的DOX释放†

我们已经构建了能够响应MUC1和端粒酶并实现细胞内药物释放的多功能载药纳米探针。此外，合成的载药纳米探针可以实现靶向肿瘤细胞膜的纳米探针，跨膜进入细胞质以及DOX释放到细胞核的全过程的原位成像观察。

更新日期：2018-07-02

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