Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer.,Genetics in Medicine

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Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer.
Genetics in Medicine ( IF 8.8 ) Pub Date : 2019-Jan-01 , DOI: 10.1038/s41436-018-0009-5
Matthew B Yurgelun _{1,

2} , Anu B Chittenden ₁ , Vicente Morales-Oyarvide ₁ , Douglas A Rubinson _{1,

2} , Richard F Dunne ₃ , Margaret M Kozak ₄ , Zhi Rong Qian _{1,

5} , Marisa W Welch ₁ , Lauren K Brais ₁ , Annacarolina Da Silva _{1,

5} , Justin L Bui ₄ , Chen Yuan _{1,

6} , Tingting Li ₅ , Wanwan Li ₅ , Atsuhiro Masuda ₅ , Mancang Gu ₅ , Andrea J Bullock ₇ , Daniel T Chang ₄ , Thomas E Clancy ₈ , David C Linehan ₉ , Jennifer J Findeis-Hosey ₁₀ , Leona A Doyle ₁₁ , Aaron R Thorner _{1,

12} , Matthew D Ducar ₁₂ , Bruce M Wollison ₁₂ , Natalia Khalaf ₂ , Kimberly Perez _{1,

2} , Sapna Syngal _{1,

2} , Andrew J Aguirre ₂ , William C Hahn _{1,

2,

12} , Matthew L Meyerson _{1,

2,

12,

13} , Charles S Fuchs _{1,

2,

14} , Shuji Ogino _{1,

5,

6,

11} , Jason L Hornick ₁₁ , Aram F Hezel ₃ , Albert C Koong _{4,

15} , Jonathan A Nowak _{5,

11} , Brian M Wolpin _{1,

2}

Affiliation

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Department of Medicine, Brigham & Women's Hospital, Boston, MA, USA.
Department of Medicine, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA.
Department of Radiation Oncology, Stanford Cancer Institute, Stanford, CA, USA.
Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Department of Surgery, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
Department of Surgery, University of Rochester Medical Center, Rochester, NY, USA.
Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA.
Department of Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA, USA.
Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Germline variants in double-strand DNA damage repair (dsDDR) genes (e.g., BRCA1/2) predispose to pancreatic adenocarcinoma (PDAC) and may predict sensitivity to platinum-based chemotherapy and poly(ADP) ribose polymerase (PARP) inhibitors. We sought to determine the prevalence and significance of germline cancer susceptibility gene variants in PDAC with paired somatic and survival analyses.

中文翻译：

生殖系癌症易感性基因变异、体细胞第二次打击以及切除胰腺癌患者的生存结果。

双链 DNA 损伤修复 (dsDDR) 基因（例如 BRCA1/2）的种系变异易患胰腺癌 (PDAC)，并可预测对铂类化疗和聚 (ADP) 核糖聚合酶 (PARP) 抑制剂的敏感性。我们试图通过配对体细胞分析和生存分析来确定 PDAC 中种系癌症易感性基因变异的患病率和意义。

更新日期：2018-07-03

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