Despite much effort has been done to improve the design of magnetic surface-enhanced Raman spectroscopy (SERS) substrates, it still remains a great challenge to develop a clean and efficient substrate for quick and sensitive target detection incorporating with separation and enrichment. Herein, we proposed the synthesis of a three-dimensional structure of Au nanoparticles/reduced graphene oxide/nickel foams (AuNPs/rGO/NFs) for improving SERS detection. The reduced graphene is firstly prepared on the surface of the nickel foams through surface reduction reaction, and then the Au NPs was formed in-situ on the rGO/NFs. Taking advantage of the magnetic properties of nickel foams, the adsorption of graphene and porous nickel foams, and hot spots of Au nanoparticles, the AuNPs/rGO/NFs-based SERS assay can probe 4-pyridinethiol and 6-mercaptopurine as low as 5 × 10⁻¹⁰ M.

尽管已经做了很多努力来改善磁性表面增强拉曼光谱（SERS）底物的设计，但是仍然需要开发一种清洁，有效的底物，以进行快速灵敏的目标检测以及分离和富集，这仍然是一个巨大的挑战。在这里，我们提出了三维金纳米颗粒/还原氧化石墨烯/镍泡沫（AuNPs / rGO / NFs）的三维结构的合成，以改善SERS检测。首先通过表面还原反应在泡沫镍的表面制备还原石墨烯，然后在rGO / NFs上原位形成Au NPs。利用镍泡沫的磁性，石墨烯和多孔镍泡沫的吸附以及Au纳米颗粒的热点，^-10M。