Studies on simultaneous synthesis of the reaction-separation processes are limited. The initial step is choosing a method to generate all possible arrangements. In this work, the Separation matrix algorithm previously developed by the authors has been expanded to include the reaction part of the process to form a Reaction/Distillation matrix.

In order to achieve a comprehensive algorithm, initially all feasible matrices have been analyzed to find common points among non-synthesizable matrices. The ability of new matrix to include a broad selection of flowsheets has then been investigated. A single two-component reaction, is assumed to prevail within a four-component mixture, the fourth being the initially nonexistent reaction product. A systematic approach is presented to determine a large selection of sequences for a four-component system including three distillation columns (simple or complex) and a reactor. A practical case study of the isomerization of n-Butane has been analyzed using the procedure developed here.

同时进行反应分离过程合成的研究是有限的。第一步是选择一种生成所有可能布置的方法。在这项工作中，作者先前开发的分离矩阵算法已得到扩展，以包括过程的反应部分以形成反应/蒸馏矩阵。

为了获得全面的算法，最初对所有可行矩阵进行了分析，以找到不可合成矩阵之间的共同点。然后，研究了新矩阵包含多种流程图的能力。假定单一的两组分反应在四组分混合物中占主导地位，第四个是最初不存在的反应产物。提出了一种系统的方法来确定包括三个蒸馏塔（简单或复杂）和反应器的四组分系统的大量序列选择。使用此处开发的方法分析了正丁烷异构化的实际案例研究。