Controllable magnetic hybrid microswimmers with hollow helical structures are fabricated, by a facile strategy based on microfluidic template synthesis and biosilicification, to achieve enhanced rotation-based locomotion for cargo transport. The magnetic hybrid microswimmers are fabricated by first synthesizing Fe₃O₄-nanoparticles-containing helical Ca-alginate microfibers from microfluidics, followed with biosilicification and controllable dicing to engineer their rigid hollow helical structures. The microswimmers show hollow helical structures consisting of a rigid, biocompatible alginate/protamine/silica shell embedded with Fe₃O₄ nanoparticles. Their helical structures can be engineered into open tubular structures or closed compartmental structures by using microfibers or diced microfibers as templates for biosilicification. Powered by a simple rotating magnet, the microswimmers can achieve enhanced rotation-based locomotion and provide good mechanical strength for supporting cargo for transportation. This work provides a simple and efficient strategy for fabricating controllable magnetic hybrid microswimmers with hollow helical structures to achieve enhanced rotation-based locomotion for cargo transport, encapsulation, and delivery.

中文翻译：

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具有空心螺旋结构的磁性混合微泳器的可控微流体制备

通过基于微流模板合成和生物硅化的简便策略，制造了具有中空螺旋结构的可控磁性杂化微泳器，以实现基于旋转的货物运输运动。通过首先从微流控材料合成含Fe ₃ O ₄纳米颗粒的螺旋藻酸钙微纤维，然后进行生物硅化和可控切割以制造其刚性空心螺旋结构，来制造磁性杂化微掠物。微泳器显示出空心的螺旋结构，该结构由嵌入了Fe ₃ O ₄的刚性，生物相容性藻酸盐/鱼精蛋白/二氧化硅壳组成纳米粒子。通过使用微纤维或切块的微纤维作为生物硅化的模板，可以将它们的螺旋结构工程化为开放的管状结构或封闭的隔室结构。由一个简单的旋转磁铁提供动力，微型游泳者可以实现基于旋转的增强运动，并为支撑运输货物提供良好的机械强度。这项工作提供了一种简单有效的策略，用于制造具有中空螺旋结构的可控磁性混合微泳器，以实现用于货物运输，封装和交付的增强的基于旋转的运动。