Abstract Out of the plethora of sensors being developed using carbon dots, the use of green alternatives with the potential of multi-functionality is still in its infancy. In view of this, the present work shows the use of Rosa indica derived heteroatom i.e. nitrogen and sulfur co-doped rose carbon dot (N-S@RCD) for dual fluorescence based sensing of multi-analytes. The N-S@RCD shows interesting fluorescence turn “off-on-off” response towards S2− and Au3+ with limit of detection (LOD) 92.4 nM and 63.1 nM, respectively. To the best of our knowledge, this is first report on direct “Turn-on” of c-dots with S2− ions without any intermediate c-dot–quencher complex. Further, the bioimaging and flow cytometry studies revealed the potential of live cell imaging, intracellular sensing and cytocompatibility of N-S@RCD. The hemocompatibility of N-S@RCD was also investigated for potential in vivo applications. Moreover, the “off-on-off” fluorescence behaviour was used to construct molecular logic gates which simulate single input logic “YES” and multi-input “INHIBIT” logic system.

中文翻译：

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采用NS共掺杂碳点的用于Au 3+ 和S 2− 的多功能荧光“关-开-关”纳米传感器

摘要 在大量使用碳点开发的传感器中，具有多功能潜力的绿色替代品的使用仍处于起步阶段。鉴于此，目前的工作显示了使用 Rosa indica 衍生的杂原子，即氮和硫共掺杂玫瑰碳点 (NS@RCD) 用于基于双荧光的多分析物传感。NS@RCD 对 S2− 和 Au3+ 显示出有趣的荧光“关-开-关”响应，检测限 (LOD) 分别为 92.4 nM 和 63.1 nM。据我们所知，这是第一个关于直接“开启”带有 S2− 离子的 c-dots 的报告，没有任何中间 c-dot-quencher 复合物。此外，生物成像和流式细胞术研究揭示了 NS@RCD 的活细胞成像、细胞内传感和细胞相容性的潜力。还研究了 NS@RCD 的血液相容性以用于潜在的体内应用。此外，“关-开-关”荧光行为用于构建模拟单输入逻辑“YES”和多输入“INHIBIT”逻辑系统的分子逻辑门。