Two Keggin polyoxometalate (POMs) based hybrid compounds containing helix/nanocages as peroxidase-like mimics have been synthesized and structurally characterized. Single crystal X-ray diffraction analysis reveals that compound 1 exhibits a POM-pillared framework with open nanotube channels (ca. 5.6 × 5.8 Ų), in which SiW₁₂ polyanions are sandwiched between the adjacent Cu-fkz sheets with meso-helix. And an unprecedented twisted octahedral hexamer nanocage (ca. 10 × 10 Ų) is observed in compound 2. Compared with the other POMs involved peroxidase-like mimics, both compounds 1 and 2 exhibit higher peroxidase-like catalytic activities, broader applications range, faster respond time and lower detection limit, which maybe attribute to the maximized synergistic effects of SiW₁₂ clusters, fkz molecules, metal ions and the distinct structure. Based on the facts, compounds 1 and 2 as enzyme mimics might expand their application around physiological pH conditions, and can be used as one kind of effective probe to detect H₂O₂ in live organism.

已经合成了两种基于Keggin多金属氧酸盐（POM）的杂合化合物，其中包含螺旋/纳米位作为过氧化物酶样模拟物。单晶X射线衍射分析表明，化合物1只显示出一个POM柱撑框架具有开放的纳米管通道（约5.6×5.8埃²），其中，硅钨酸₁₂聚阴离子被夹有内消旋-螺旋的相邻的Cu-FKZ片之间。和一个前所未有的扭曲八面体六聚体纳米笼（约10×10埃²）在化合物中观察到2。与其他过氧化物酶样模拟物相比，化合物1和2表现出更高的过氧化物酶样催化活性，更广泛的应用范围，更快的响应时间和更低的检测限，这可能归因于SiW ₁₂团簇，fkz分子，金属离子和独特结构的最大化协同效应。基于这一事实，作为酶模拟物的化合物1和2可能会在生理pH条件下扩展其应用范围，并且可以用作检测活生物体中H ₂ O _2的一种有效探针。