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Long Non-coding MIR205HG Depletes Hsa-miR-590-3p Leading to Unrestrained Proliferation in Head and Neck Squamous Cell Carcinoma
Theranostics ( IF 12.4 ) Pub Date : 2018-02-12 , DOI: 10.7150/thno.22167
Silvia Di Agostino , Fabio Valenti , Andrea Sacconi , Giulia Fontemaggi , Matteo Pallocca , Claudio Pulito , Federica Ganci , Paola Muti , Sabrina Strano , Giovanni Blandino

Over 70% of head & neck squamous cell carcinoma (HNSCC) patients carry TP53 oncogenic mutations. Here we studied the role of specific tumor-derived mutant p53 proteins in the aberrant transcription of long non-coding (lnc) MIR205HG gene in head and neck cancer cells.

中文翻译:

长的非编码MIR205HG耗尽了Hsa-miR-590-3p,导致头颈部鳞状细胞癌的增殖不受限制。

超过70%的头颈部鳞状细胞癌(HNSCC)患者携带TP53致癌突变。在这里,我们研究了特定的肿瘤衍生突变体p53蛋白在头颈部癌细胞中长非编码(lncMIR205HG基因异常转录中的作用。
更新日期:2018-07-01
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