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Cell-penetrating Peptide-modified Targeted Drug-loaded Phase-transformation Lipid Nanoparticles Combined with Low-intensity Focused Ultrasound for Precision Theranostics against Hepatocellular Carcinoma
Theranostics ( IF 12.4 ) Pub Date : 2018-02-14 , DOI: 10.7150/thno.22386 Hongyun Zhao , Meng Wu , Leilei Zhu , Yi Tian , Mingxing Wu , Yizhen Li , Liming Deng , Wei Jiang , Wei Shen , Zhigang Wang , Zhechuan Mei , Pan Li , Haitao Ran , Zhiyi Zhou , Jianli Ren
Theranostics ( IF 12.4 ) Pub Date : 2018-02-14 , DOI: 10.7150/thno.22386 Hongyun Zhao , Meng Wu , Leilei Zhu , Yi Tian , Mingxing Wu , Yizhen Li , Liming Deng , Wei Jiang , Wei Shen , Zhigang Wang , Zhechuan Mei , Pan Li , Haitao Ran , Zhiyi Zhou , Jianli Ren
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Objective: Prepare a multifunctional ultrasound molecular probe, hyaluronic acid-mediated cell-penetrating peptide-modified 10-hydroxycamptothecin-loaded phase-transformation lipid nanoparticles (HA/CPPs-10-HCPT-NPs), and to combine HA/CPPs-10-HCPT-NPs with low-intensity focused ultrasound (LIFU) for precision theranostics against hepatocellular carcinoma (HCC).
中文翻译：
细胞穿透肽修饰的靶向药物负载的相变脂质纳米粒子与低强度聚焦超声相结合对肝细胞癌的精确治疗学研究。
目的：制备多功能超声分子探针，透明质酸介导的细胞穿透肽修饰的10-羟基喜树碱加载的相变脂质纳米粒子（HA / CPPs-10-HCPT-NPs），并结合HA / CPPs-10-具有低强度聚焦超声（LIFU）的HCPT-NP用于肝细胞癌（HCC）的精确诊断。
更新日期：2018-07-01
中文翻译：
细胞穿透肽修饰的靶向药物负载的相变脂质纳米粒子与低强度聚焦超声相结合对肝细胞癌的精确治疗学研究。
目的：制备多功能超声分子探针，透明质酸介导的细胞穿透肽修饰的10-羟基喜树碱加载的相变脂质纳米粒子（HA / CPPs-10-HCPT-NPs），并结合HA / CPPs-10-具有低强度聚焦超声（LIFU）的HCPT-NP用于肝细胞癌（HCC）的精确诊断。
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