Rice bran is obtained from the rice polishing process, and this by-product contains many bioactive compounds. In this study, the composition of phenolic compounds from red and black rice brans was determined by HPLC−DAD−MS. Additionally, the neuroprotective ability of these brans in SH-SY5Y cells insulted with hydrogen peroxide (H₂O₂) was evaluated. The phenolic constituents of rice bran were separated into hydrophilic and pellet fractions. The major phenolic compound in both samples was ferulic acid. Cyanidin 3-glucoside was the main anthocyanin in black rice bran. The hydrophilic and pellet fractions showed a protective effect (38–94%) on SH-SY5Y cells insulted by H₂O₂ in DCFH-DA assay. No extract showed cytotoxicity in the SRB assay. These results suggest a neuroprotective effect of red and black rice brans extracts due to their high antioxidant capacity, along with the absence of cytotoxicity. Thus, they may potentially be used as sources of bioactive compounds.

米糠是从大米抛光过程中获得的，该副产物包含许多生物活性化合物。在这项研究中，通过HPLC-DAD-MS测定了红米糠和黑米糠中酚类化合物的组成。另外，评估了这些麸在被过氧化氢（H ₂ O ₂）侵害的SH-SY5Y细胞中的神经保护能力。米糠中的酚类成分被分为亲水部分和颗粒部分。两个样品中的主要酚类化合物均为阿魏酸。氰胺3-葡萄糖苷是黑米糠中的主要花色苷。亲水部分和沉淀部分对H ₂ O ₂损伤的SH-SY5Y细胞具有保护作用（38-94％）。在DCFH-DA分析中。在SRB分析中没有提取物显示出细胞毒性。这些结果表明，由于红色和黑色米糠提取物的高抗氧化能力以及不具有细胞毒性，因此具有神经保护作用。因此，它们可能潜在地用作生物活性化合物的来源。