A Light‐Up Probe with Aggregation‐Induced Emission for Real‐Time Bio‐orthogonal Tumor Labeling and Image‐Guided Photodynamic Therapy,Angewandte Chemie International Edition

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A Light‐Up Probe with Aggregation‐Induced Emission for Real‐Time Bio‐orthogonal Tumor Labeling and Image‐Guided Photodynamic Therapy
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2018-07-18 , DOI: 10.1002/anie.201805446
Fang Hu ₁ , Duo Mao ₁ , Kenry ₁ , Xiaolei Cai ₁ , Wenbo Wu ₁ , Deling Kong ₂ , Bin Liu ₁

Affiliation

Bio‐orthogonal tumor labeling is more effective in delivering imaging agents or drugs to a tumor site than active targeting strategy owing to covalent ligation. However, to date, tumor‐specific imaging through bio‐orthogonal labeling largely relies on body clearance to differentiate target from the intrinsic probe signal owing to the lack of light‐up probes for in vivo bio‐orthogonal labeling. Now the first light‐up probe based on a fluorogen with aggregation‐induced emission for in vivo bio‐orthogonal fluorescence turn‐on tumor labeling is presented. The probe has low background fluorescence in aqueous media, showing negligible non‐specific interaction with normal tissues. Once it reacts with azide groups introduced to tumor cells through metabolic engineering, the probe fluorescence is lightened up very quickly, enabling rapid tumor‐specific imaging. The photosensitizing ability was also used to realize effective image‐guided photodynamic tumor therapy.

中文翻译：

具有聚集诱导发射的实时生物正交肿瘤标记和图像引导光动力疗法的光探针。

由于共价连接，生物正交肿瘤标记比主动靶向策略更有效地将成像剂或药物递送至肿瘤部位。然而，迄今为止，由于缺乏用于体内生物正交标记的发光探针，通过生物正交标记的肿瘤特异性成像很大程度上依赖于体内清除率才能将靶标与固有探针信号区分开。现在，提出了第一种基于荧光素的聚光诱导探针，用于体内生物正交荧光开启肿瘤标记。该探针在水性介质中的背景荧光很低，与正常组织的非特异性相互作用可忽略不计。一旦它与通过代谢工程引入肿瘤细胞的叠氮化物基团发生反应，探针的荧光就会很快变亮，能够快速进行肿瘤特异性成像。光敏能力也被用于实现有效的图像引导的光动力肿瘤治疗。

更新日期：2018-07-18

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