[Ru₂Cl₂(DPhF)₃] (DPhF = diphenylformamidinate) links preferentially to the junctions of RNA (ribonucleic acid) structures, although the bonding mode is not known. In order to clarify this question the reactions between [Ru₂Cl₂(DPhF)₃] and cytosine (Hcyto), cytidine (Hcyti), cytidine 2′,3′-cyclic monophosphate sodium salt (NacCMP), adenine (Hade), adenosine (Haden) and adenosine 3′,5′-cyclic monophosphate (HcAMP) have been carried out. In the resultant complexes, cyto (cytosinate), cyti (cytidinate), cCMP (cytidine 2′,3′-cyclic monophosphate monoanion), ade (adeninate), aden (adenosinate) and cAMP (deprotonated adenosine 3′,5′-cyclic monophosphate) are bonded to the diruthenium unit as N,N′-bridging ligands, as confirmed by the solution of the crystal structures of [RuCl(DPhF)₃(cyto)] and [RuCl(DPhF)₃(ade)] by X-ray diffraction. The axial positions of the diruthenium species are still available for additional interactions with other residues that could explain its preference towards RNA junctions.

[Ru ₂ Cl ₂（DPhF）₃ ]（DPhF =二苯基甲酰胺酸酯）优先连接到RNA（核糖核酸）结构的连接处，尽管键的模式尚不清楚。为了阐明这个问题，[Ru ₂ Cl ₂（DPhF）₃]和胞嘧啶（Hcyto），胞苷（Hcyti），胞苷2'，3'-环一磷酸钠（NacCMP），腺嘌呤（Hade），腺苷（Haden）和腺苷3'，5'-环一磷酸（HcAMP）进行了。在所得的复合物中，细胞（胞嘧啶），胞嘧啶（胞嘧啶），cCMP（胞苷2'，3'-环一磷酸单阴离子），ade（腺苷），aden（腺苷酸）和cAMP（去质子化腺苷3'，5'-环状单磷酸）作为N，N '桥键配体键合到二钌单元上，如[RuCl（DPhF）₃（细胞）]和[RuCl（DPhF）₃的晶体结构的溶液所证实（ade）]通过X射线衍射。钌物种的轴向位置仍可用于与其他残基的其他相互作用，这可能解释了其对RNA连接的偏好。