Usually the tumor thermal therapy is accompanied with inflammatory reactions, which in turn promote tumor growth and metastasis meanwhile. Herein, we prepared novel trifunctional PEG-IL/ZrO₂-Ag@SiO₂ nanorattles, which can be used for CT imaging-guided simultaneous tumor microwave thermal therapy and resistance to bacterial infection. Under the microwave irradiation, the nanorattles present excellent microwave thermal properties. Simultaneously, the nanorattles have good antibacterial effect in vitro and in vivo, which can restrain bacterial growth effectively and reduce inflammation response during the microwave thermal therapy. In addition, the nanorattles also have the function of CT imaging, which can monitor the tumor therapy in real time. The strategy of simultaneous microwave thermal therapy and inflammation management effectively inhibits tumor growth in mice with a good anti-tumor effect (96.4%). This proof-of-concept investigation provides a simple and reliable strategy for tumor treatment and inhibiting inflammatory reaction using a multifunctional nanomaterial, indicating the great application prospect in tumor treatment by simultaneous eradicating tumor tissue and managing inflammation.

通常，肿瘤热疗法会伴有炎症反应，这反过来又促进了肿瘤的生长和转移。本文中，我们制备了新颖的三官能团PEG-IL / ZrO ₂ -Ag @ SiO ₂纳米ra，可用于CT成像引导的同步肿瘤微波热疗和对细菌感染的抵抗力。在微波辐射下，纳米ra呈现出优异的微波热性能。同时，纳米ra在体外和体内均具有良好的抗菌作用，可以有效抑制细菌生长，减少微波热疗过程中的炎症反应。另外，纳米ra还具有CT成像功能，可以实时监测肿瘤的治疗情况。同时进行微波热疗和炎症控制的策略有效抑制了小鼠的肿瘤生长，并具有良好的抗肿瘤效果（96.4％）。