Radiolabeled nanomaterials, especially those with ultra-small structures, have been the research focus in recent years, and thus may open up new prospects for clinical diseases theranostics. Herein, fluorinated Pd nanosheets labeled with Gd or radionuclides are developed as multimodal platforms for tumor theranostics. These nanomaterials decorated by functional polyethylene glycol demonstrate ultrahigh ¹⁹F MRI signal, ultrasmall size and good dispersion. These ultrasmall materials exhibit good biocompatibility and easily to be modified for multimodal imaging (SPECT/MRI/PAI) by assembling the functional groups like building blocks. Furthermore, with high accumulation in tumor sites, under the guidance of multimodal imaging, combined photothermal therapy and radiotherapy are performed and synergistic effects are obtained. By comparing the in vivo behaviors of nanostructures labeled by different nuclides, the present study suggests the pH-sensitive radioiodinated Pd nanosheet which has unexpected T/NT ratio (>4-fold tumor-to-muscle ratio) in SPECT imaging and solves the critical high background issue of nanoprobes, could improve diagnostic accuracy and guide combination therapy. In summary, this functionalized nanoplatform with promising imaging and therapeutic efficacy has great potential for precision theranostic nanomedicines.

近年来，放射性标记的纳米材料，尤其是具有超小结构的纳米材料已经成为研究的热点，因此可能为临床疾病治疗学开辟新的前景。在本文中，被标记为Gd或放射性核素的氟化Pd纳米片被开发为肿瘤治疗学的多峰平台。这些由功能性聚乙二醇修饰的纳米材料表现出超高¹⁹F MRI信号，超小尺寸，分散性好。这些超小型材料表现出良好的生物相容性，并且可以通过组装类似构造基团的官能团轻松地用于多峰成像（SPECT / MRI / PAI）。此外，在肿瘤部位高积累的情况下，在多模式成像的指导下，进行了光热疗法和放射疗法的组合，并获得了协同作用。通过比较体内由不同核素标记的纳米结构的行为，本研究表明pH敏感的放射性碘化Pd纳米片在SPECT成像中具有出乎意料的T / NT比（> 4倍的肿瘤与肌肉比），并解决了纳米探针的关键高本底问题，可以提高诊断准确性并指导联合治疗。总而言之，这种具有前景的成像和治疗功效的功能化纳米平台具有用于精确治疗性纳米医学的巨大潜力。