To reduce the effects of greenhouse gas emissions on climate change, scientific efforts have sought to develop biofuels and bio‐based commodity chemicals as petrochemical replacements primarily for their environmental benefits. As the biological design space is far greater than chemical synthesis, there has been a drive to leverage this ability to create and replace fine and specialty chemicals. While polyketide synthases have traditionally been studied for their biosynthesis of pharmaceutical chemicals, the unique advantages of engineering polyketide synthases for the production of biofuels, commodity chemicals, and both pharmaceutical and nonpharmaceutical fine and specialty chemicals are discussed. With our increased understanding of polyketide biosynthetic logic, new computational tools for prospective polyketide synthesis pathways for the creation of existing and novel biochemicals are also outlined. © 2018 American Institute of Chemical Engineers AIChE J, 64: 4201–4207, 2018

中文翻译：

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聚酮化合物合酶作为化学产品设计的平台

为了减少温室气体排放对气候变化的影响，科学上的努力已寻求开发生物燃料和基于生物的商品化学品作为石化化学品的替代品，主要是为了它们的环境效益。由于生物设计空间远远大于化学合成，因此人们一直在利用这种能力来创建和替代精细化学品和特种化学品。尽管传统上已经研究了聚酮化合物合酶的生物化学合成方法，但仍讨论了工程聚酮化合物合酶在生产生物燃料，日用化学品以及制药和非制药精细及特种化学品中的独特优势。随着我们对聚酮化合物生物合成逻辑的深入了解，还概述了用于创建现有和新型生化试剂的预期聚酮化合物合成途径的新计算工具。©2018美国化学工程师学会AIChE J，64：4201–4207，2018